Cannabidiol (CBD) has become increasingly popular as a potential remedy for a variety of health issues, including anxiety, epilepsy, and pain control. Research has shown that CBD, often in combination with THC, is an effective pain reliever for various chronic conditions. CBD does not bind to endocannabinoid receptors very well, but it does interact with neurological receptors in the spinal cord that suppress chronic inflammatory pain. It can also reinforce the effects of AEA, an endogenous cannabinoid that reduces pain.
Chronic pain is defined as any pain that lasts longer than several months. Studies have demonstrated that CBD can interact with several CYP450 enzymes involved in drug metabolism, raising concerns about possible drug interactions. The anti-rolling effect of CBD after 30 minutes was blocked by CB2 and TRPV1 antagonists, but not by a CB1 antagonist. CBD itself does not produce the typical behavioral cannabinoimimetic effects and was thought not to be responsible for the psychotropic effects of cannabis.
On the other hand, the targets of GPCRs and transporters represent a link between the actions of CBD and the endocannabinoid system due to the high activity of CBD for FABP proteins and the allosteric modulation of cannabinoid receptors. CBD has been found to reduce inflammation in the joints, especially when it comes to osteoarthritis. This makes it an attractive alternative to traditional pain relievers, especially in light of the opioid crisis. A commentary published in the Annals of Internal Medicine by Boehnke and Daniel Clauw, M. D., provides a list of potentially effective CBD products that have undergone extensive third-party safety testing. When using CBD for wounds or blisters, you may want to apply it directly to the affected area instead of ingesting it.
In their study, CBD alone had no antinociceptive effect, but it did increase the animals' locomotor activity. CBD is gaining popularity as a promising supplement for many conditions, including pain relief. Boehnke and Clauw recommend that people with chronic pain talk to their doctor about adding CBD to their treatment plan and continue using prescription medications.