Researchers suggest that cannabis or cannabinoids may be effective in treating some types of chronic pain, including neuropathy (nerve pain). After nerve injury, neurons can become more reactive and receptive, leading to the development of painful nerve endings. Cannabinoids can reduce nerve pain by altering these cellular functions. Cannabinoids such as Tetrahydrocannabinol (THC) and cannabidiol (CBD) activate CB1 and CB2 receptors and help regulate neurotransmitters and the central nervous system, helping to relieve pain.
Cannabis also plays a role in the endorphin system and may reduce the patient's perception of pain, making it less intense and easier to treat. Studies suggest that THC potency affects tolerability, since higher doses cause clinically significant adverse effects, some of which may reduce the ability to perform activities of daily living. The body produces its own endocannabinoids on demand in the central nervous system, which act as a circuit breaker to reduce pain. Peripheral neuropathy is a complex chronic condition that occurs when nerve fibers are damaged, dysfunctional, or injured, and sends incorrect signals to the pain centers of the central nervous system.
THC can alter the perception of pain by reducing anxiety and stress, while CBD combats pain through its anti-inflammatory action. Inhaling cannabis formulations containing 0%, 2.5%, 6.0% and 9.4% THC for 14 days has been found to be effective in treating neuropathic pain. The answer lies in the way cannabis interacts with our endocannabinoid system. Blue Dream is one of the best herbs for neuropathy on the market due to its superhigh levels of THC and profound analgesic properties.
In addition, the chemical compounds found in cannabis, called cannabinoids, bind to receptors in the brain and the peripheral nervous system. The endocannabinoid system plays an essential role in regulating neuroplasticity and central nervous system homeostasis. Studies based on NIDA varieties probably underestimate the risks of cannabis purchased by consumers, since THC is believed to be primarily responsible for the risk of psychosis and cognitive and driving problems. When bringing together four trials on smoked cannabis, it was found that the analgesic effect is evident, that this effect may be useful for some patients and that it often entails some adverse effects on the central nervous system.