Cannabidiol (CBD) is a chemical compound derived from Cannabis sativa, and is widely known for its non-psychoactive properties. While there is no clear evidence to suggest that CBD can increase feelings of depression, it is important to be aware of the potential side effects, such as fatigue. Additionally, research suggests that regular or heavy marijuana users may be more likely to be diagnosed with depression than non-smokers. However, marijuana does not appear to directly cause depression.
Due to genetic variety, age and pre-existing conditions, people usually have different reactions to cannabis. Therefore, it is possible that cannabis can make you depressed. To avoid this, it is important to approach cannabis use with the right intention and control both the composition and the dose. Fortunately, brands like Koan Cordials make it easier to identify dosed cannabis and focus on mental health.
The Food and Drug Administration (FDA) has not approved over-the-counter CBD products, and some products may be mislabeled. In a small study of 11 patients with post-traumatic stress disorder (PTSD), CBD was administered orally on an open label and the patient's PTSD symptoms were evaluated initially and on consecutive days up to 8 weeks after using the PCL-5 test and score. In a mouse model with hippocampal gliosis induced by the injection of a human A beta fragment, CBD inhibited glial cell activation and release of the proinflammatory mediator in a dose-dependent manner. Preclinical studies have shown some promising data on the medicinal value of CBD, but human studies have no consistent results and their design is controversial.
In vitro, CBD has been shown to decrease local epileptiform field potentials, their breadth and duration.