When it comes to pain relief, cannabinoids are one of the most effective compounds found in the cannabis plant. Cannabinoids, such as THC and CBD, interact with the body's cannabinoid receptors, which are located in nerve cells and immune cells. This interaction helps to reduce the sensation of pain and inflammation, providing relief from a variety of conditions. Research has shown that THC can provide mild to moderate pain relief, similar to that of codeine.
In one study, 10 milligrams of THC was found to be as effective as a 60-milligram dose of codeine. Furthermore, 20 milligrams of THC was found to be as effective as 120 milligrams of codeine. Interestingly, none of the patients experienced nausea or vomiting and more than half reported that their appetite had increased, suggesting that oral THC acted as an antiemetic and appetite stimulant, as well as a pain reliever. To maintain analgesic efficacy and reduce the risk of tolerance, balanced THC and CBD products should be considered for long-term pain management.
Clinical trials could also determine if THC is the only and, if not, the best pain reliever compound in marijuana. Marijuana cigarettes contain very variable amounts of THC, usually between 30 and 150 milligrams. However, much of this THC is lost in uninhaled smoke due to tolerance to the activation of CB1 receptors by THC. Synthetic products with high THC-CBD ratios were associated with moderate pain improvements, while plant-based products with comparable THC to CBD ratios offered less relief. Overall, research has shown that THC can provide mild to moderate pain relief similar to that of codeine.
To maintain analgesic efficacy and reduce the risk of tolerance, balanced THC and CBD products should be considered for long-term pain management.
